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Glycyrrhizin prevents 3-nitropropionic acid-induced neurotoxicity by downregulating HMGB1/TLR4/NF-κB p65 signaling, and attenuating oxidative stress, inflammation, and apoptosis in rats

Abdallah M. Gendy, Hagar M. El-Sadek, Mohamed M. Amin, Kawkab A. Ahmed, Mohamed Kotb El-Sayed, Alaadin E. El-Haddad, Ayman A. Soubh

2022Life Sciences39 citationsDOI

Topics & Concepts

Oxidative stressGlycyrrhizinNeuroprotectionPharmacologyInflammationNeurotoxicityHMGB1ApoptosisTLR4ChemistryKEAP1NeurodegenerationToxicityMedicineBiochemistryInternal medicineGeneTranscription factorDiseaseGenetic Neurodegenerative DiseasesTryptophan and brain disordersParkinson's Disease Mechanisms and Treatments
Glycyrrhizin prevents 3-nitropropionic acid-induced neurotoxicity by downregulating HMGB1/TLR4/NF-κB p65 signaling, and attenuating oxidative stress, inflammation, and apoptosis in rats | Litcius