Oxygen Migration–Defluorination Strategy Enables the Aminocarbonylation of Enaminones with <i>o</i>-Aminobenzamides and CF<sub>2</sub>Br<sub>2</sub>
Wanqing Zuo, Renhua Zheng, Yinghong Huang, Xiao Geng, Lingling Zuo, Lei Wang
Abstract
The development of different concept approaches and user-friendly carbonyl surrogates for aminocarbonylation is highly desirable. Herein, we report the photocatalytic aminocarbonylation of enaminones with easily available o -aminobenzamides and CF 2 Br 2 through an oxygen migration–defluorination strategy. The reaction features switchable transformation for the construction of carbamoyl-substituted enaminones and enol products and allows the expedient synthesis of fully substituted maleimides under mild reaction conditions.
Topics & Concepts
ChemistryOxygenMolecular oxygenCombinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryFluorine in Organic ChemistryChemical Synthesis and AnalysisSynthesis and Catalytic Reactions