Asymmetric Oxidative Mannich Reactions
Jaume Rostoll‐Berenguer, Gonzalo Blay, José R. Pedro, Carlos Vila
Abstract
Abstract The asymmetric Mannich reaction is one of the most straightforward methodologies for the enantioselective synthesis of chiral amines. In general, asymmetric Mannich reactions involve the use of imines as electrophiles. However, in recent years, several asymmetric oxidative Mannich reactions have been reported using amines as electrophiles. This review provides an overview of these recent publications, including the different oxidants used and the scope and limitations of the different catalytic systems. magnified image
Topics & Concepts
ElectrophileChemistryEnantioselective synthesisMannich reactionScope (computer science)Combinatorial chemistryOrganocatalysisCatalysisOrganic chemistryOxidative phosphorylationComputer scienceBiochemistryProgramming languageSynthesis and Catalytic ReactionsAsymmetric Synthesis and CatalysisOxidative Organic Chemistry Reactions