GYS1 induces glycogen accumulation and promotes tumor progression via the NF-κB pathway in Clear Cell Renal Carcinoma
Shi‐Lu Chen, Qunsheng Huang, Yuhua Huang, Xia Yang, Mingming Yang, Yangfan He, Yun Cao, Xin‐Yuan Guan, Jing‐Ping Yun
Abstract
Our study findings reveal an oncogenic role for GYS1 in cell proliferation and glycogen metabolism in ccRCC. Re-sensitization of ccRCC cells to sunitinib suggests that GYS1 is a useful indicator of unfavorable prognosis as well as a therapeutic target for patients with ccRCC.
Topics & Concepts
GlycogenCancer researchGlycogen synthaseRenal cell carcinomaCancerClear cellClear cell renal cell carcinomaTumor progressionCytoplasmCellChemistryBiologyEndocrinologyInternal medicineMedicineCell biologyBiochemistryEpigenetics and DNA MethylationWnt/β-catenin signaling in development and cancerGenetics and Neurodevelopmental Disorders