Ingestion of <i>Lacticaseibacillus rhamnosus</i> Fmb14 prevents depression-like behavior and brain neural activity <i>via</i> the microbiota–gut–brain axis in colitis mice
Hongyuan Zhao, Xiaoyu Chen, Li Zhang, Chao Tang, Fanqiang Meng, Libang Zhou, Zhu Ping, Zhaoxin Lu, Yingjian Lu
Abstract
increased levels of ZO1 and Ocln. Moreover, brain activity was facilitated by an increase in BDNF and dopamine and the downregulation of GABA in the Fmb14 group. As a consequence of the modulatory effect on the dysfunction of neurotransmitters and neuroinflammation, Fmb14 prevents neurodegeneration by inhibiting neuronal apoptosis and Nissl edema. In addition, the correlation analysis further demonstrated the preventative effect of Fmb14 on depression-like behavior through the microbiota-gut-brain axis. Together, these findings demonstrated the important role of Fmb14 in biological signal transduction over the microbiota-gut-brain axis to improve mood disorders.