tRNA-derived fragment tRF-1001: A novel anti-angiogenic factor in pathological ocular angiogenesis
Qin Jiang, Yan Ma, Ya Zhao, Mu-Di Yao, Yan Zhu, Qiuyang Zhang, Biao Yan
Abstract
. Mechanistically, tRF-1001 regulated endothelial angiogenic effects via tRF-1001/METTL3/RBPJ-MAML1 signaling. The levels of tRF-1001 expression were downregulated in the aqueous humor of age-related macular degeneration (AMD) patients. tRF-1001 upregulation could suppress AMD aqueous humor-induced endothelial sprouting and pathological angiogenesis. Collectively, tRF-1001 acts as an anti-angiogenic factor during ocular angiogenesis. Targeting tRF-1001-mediated signaling is a therapeutic option for ocular neovascular diseases.
Topics & Concepts
AngiogenesisSprouting angiogenesisNeovascularizationCancer researchChoroidal neovascularizationBiologyDownregulation and upregulationCell biologyRetinalGeneticsGeneBiochemistryCancer-related molecular mechanisms researchRNA modifications and cancerinterferon and immune responses