A bilayer hydrogel mimicking the periosteum-bone structure for innervated bone regeneration
Wenhui Lyu, Yuyue Zhang, Shaopei Ding, Xiang Li, Tong Sun, Jun Luo, Jian Wang, Jianshu Li, Lei Li
Abstract
experiments demonstrated that the GS@Mg/GP@nHA hydrogel efficiently promoted nerve network reconstruction and bone regeneration of rat calvarial bone defects. Altogether, the bilayer hydrogel GS@Mg/GP@nHA could promote innervated bone regeneration, providing new insights for biomaterial design for bone tissue engineering.
Topics & Concepts
PeriosteumMaterials scienceRegeneration (biology)BilayerAnatomyBiomedical engineeringCell biologyMedicineChemistryMembraneBiologyBiochemistryBone Tissue Engineering Materials3D Printing in Biomedical ResearchHydrogels: synthesis, properties, applications