Trifluoromethyl-substituted 3,5-bis(arylidene)-4-piperidones as potential anti-hepatoma and anti-inflammation agents by inhibiting NF-кB activation
Wei Cong, Yue Sun, Yifan Sun, Wei-Bin Yan, Yulong Zhang, Zhongfei Gao, Chunhua Wang, Gui‐Ge Hou, Jiajing Zhang
Abstract
has enormous potential to be developed as a multifunctional agent for the clinical treatment of liver cancers and inflammatory diseases.
Topics & Concepts
TrifluoromethylApoptosisChemistryp38 mitogen-activated protein kinasesNF-κBInflammationDocking (animal)MAPK/ERK pathwayPhosphorylationStereochemistryCancer researchCellPharmacologyBiochemistryBiologyImmunologyMedicineOrganic chemistryAlkylNursingNF-κB Signaling PathwaysSynthesis and biological activityCytokine Signaling Pathways and Interactions