Smad3 deficiency promotes beta cell proliferation and function in <i>db/db</i> mice <i>via</i> restoring Pax6 expression
Jingyi Sheng, Li Wang, Patrick Ming‐Kuen Tang, Honglian Wang, Jianchun Li, Bihua Xu, Vivian Weiwen Xue, Ruizhi Tan, Nana Jin, Ting‐Fung Chan, Xiao‐Ru Huang, Ronald C.W., Hui-Yao Lan
Abstract
Taken together, we discovered a pathogenic role of Smad3 in beta cell loss and dysfunction via targeting the protective Pax6. Thus, Smad3 may represent as a novel therapeutic target for type 2 diabetes prevention and treatment.
Topics & Concepts
IsletBeta cellPAX6Cell growthBETA (programming language)EndocrinologyBiologyInternal medicineCellKnockout mouseCancer researchDiabetes mellitusCell biologyGeneMedicineTranscription factorGeneticsComputer scienceProgramming languagePancreatic function and diabetesGenetic Syndromes and ImprintingMetabolism, Diabetes, and Cancer