A solvent-reagent selection guide for Steglich-type esterification of carboxylic acids
Andrew Jordan, Kyran D. Whymark, Jack D. Sydenham, Helen F. Sneddon
Abstract
A solvent-reagent selection guide for Steglich esterification has been developed. Safer, more sustainable solvent-reagent combinations were identified and optimized for this transformation effectively replacing the more harmful, toxic status quo .
Topics & Concepts
ReagentSolventChemistryOrganic chemistryStatus quoSelection (genetic algorithm)Combinatorial chemistryPolitical scienceLawComputer scienceArtificial intelligenceChemistry and Chemical EngineeringComputational Drug Discovery MethodsVarious Chemistry Research Topics