Diffuse Pleural Mesothelioma: Advances in Molecular Pathogenesis, Diagnosis, and Treatment
Christopher A. Febres‐Aldana, Rachel Fanaroff, Michael Offin, Marjorie G. Zauderer, Jennifer L. Sauter, Soo‐Ryum Yang, Marc Ladanyi
Abstract
Diffuse pleural mesothelioma (DPM) is a highly aggressive malignant neoplasm arising from the mesothelial cells lining the pleural surfaces. While DPM is a well-recognized disease linked to asbestos exposure, recent advances have expanded our understanding of molecular pathogenesis and transformed our clinical practice. This comprehensive review explores the current concepts and emerging trends in DPM, including risk factors, pathobiology, histologic subtyping, and therapeutic management, with an emphasis on a multidisciplinary approach to this complex disease.
Topics & Concepts
MesotheliomaPathogenesisPleural diseaseMedicineAsbestosDiseasePathologyCancer researchRespiratory diseaseInternal medicineLungMaterials scienceMetallurgyOccupational and environmental lung diseasesPleural and Pulmonary DiseasesMedical Imaging and Pathology Studies