Haemoglobin-loaded metal organic framework-based nanoparticles camouflaged with a red blood cell membrane as potential oxygen delivery systems
Xiaoli Liu, Michelle Maria Theresia Jansman, Leticia Hosta‐Rigau
Abstract
Metal organic frameworks are used to protect hemoglobin from denaturation thus preserving its excellent oxygen-binding and releasing properties. Decorating with cell membranes minimizes protein adsorption holding potential for long circulation.
Topics & Concepts
ChemistryNanoparticleOxygenRed blood cellMembraneBlood cellBiophysicsNanotechnologyChemical engineeringMaterials scienceBiochemistryImmunologyOrganic chemistryBiologyEngineeringHemoglobin structure and functionNanoplatforms for cancer theranosticsHeme Oxygenase-1 and Carbon Monoxide