A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening <i>Acinetobacter baumannii</i>
Xukai Jiang, Nitin A. Patil, Mohammad Abul Kalam Azad, Hasini Wickremasinghe, Heidi H. Yu, Jinxin Zhao, Xinru Zhang, Mengyao Li, Bin Gong, Lin Wan, Wendong Ma, Philip E. Thompson, Kai Yang, Bing Yuan, Falk Schreiber, Lushan Wang, Tony Velkov, Kade D. Roberts, Jian Li
Abstract
antibacterial activity. Collectively, our study provides a novel chemical biology and computational strategy to expedite the discovery of new-generation polymyxins against life-threatening Gram-negative 'superbugs'.
Topics & Concepts
Acinetobacter baumanniiPolymyxinAcinetobacterAntibioticsMicrobiologyBiologyMultiple drug resistanceBacteriaComputational biologyPseudomonas aeruginosaGeneticsAntibiotic Resistance in BacteriaVibrio bacteria research studiesBacterial biofilms and quorum sensing