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Bile Acid Conjugates with Anticancer Activity: Most Recent Research

Maria Luisa Navacchia, Elena Marchesi, Daniela Perrone

2020Molecules34 citationsDOIOpen Access PDF

Abstract

The advantages of a treatment modality that combines two or more therapeutic agents in cancer therapy encourages the study of hybrid functional compounds for pharmacological applications. In light of this, we reviewed recent works on hybrid molecules based on bile acids. Due to their biological properties, as well as their different chemical/biochemical reactive moieties, bile acids can be considered very interesting starting molecules for conjugation with natural or synthetic bioactive molecules.

Topics & Concepts

ConjugateBile acidCombinatorial chemistryChemistryMoleculeCancerBiological activityBiochemistryComputational biologyBiologyOrganic chemistryIn vitroMathematical analysisGeneticsMathematicsClick Chemistry and ApplicationsDrug Transport and Resistance MechanismsHIV/AIDS drug development and treatment