Downregulated GPX4 in salivary gland epithelial cells contributes to salivary secretion dysfunction in Sjogren's syndrome via lipid ROS/pSTAT4/AQP5 axis
Jiannan Zhou, Janak L. Pathak, Lihong Wu, Bo Chen, Tingting Cao, Wei Wei, Xiaodan Wu, Guiping Chen, Nobumoto Watanabe, Xiaomeng Li, Jiang Li
Topics & Concepts
Downregulation and upregulationSecretionGene knockdownSalivary glandGPX4BiologyEndocrinologyInternal medicineWestern blotCancer researchCell biologyOxidative stressMedicineCell cultureSuperoxide dismutaseGlutathione peroxidaseBiochemistryGeneGeneticsSalivary Gland Disorders and FunctionsCancer-related molecular mechanisms researchCaveolin-1 and cellular processes