Roles of phosphatidyl inositol 3 kinase gamma (PI3Kγ) in respiratory diseases
Valentina Sala, Angela Della Sala, Alessandra Ghigo, Emilio Hirsch
Abstract
Phosphatidyl inositol 3 kinase gamma (PI3Kγ) is expressed in all the cell types that are involved in airway inflammation and disease, including not only leukocytes, but also structural cells, where it is expressed at very low levels under physiological conditions, while is significantly upregulated after stress. In the airways, PI3Kγ behaves as a trigger or a controller, depending on the pathological context. In this review, the contribution of PI3Kγ in a plethora of respiratory diseases, spanning from acute lung injury, pulmonary fibrosis, asthma, cystic fibrosis and response to both bacterial and viral pathogens, will be commented.
Topics & Concepts
Cystic fibrosisContext (archaeology)PI3K/AKT/mTOR pathwayInflammationAsthmaImmunologyMedicineRespiratory systemLungFibrosisInositolPathologicalBiologyPathologyCell biologyInternal medicineSignal transductionReceptorPaleontologyInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisNeonatal Respiratory Health ResearchNeutrophil, Myeloperoxidase and Oxidative Mechanisms