Pre-Existing Cytokine and NLRP3 Inflammasome Activation and Increased Vascular Permeability in Diabetes: A Possible Fatal Link With Worst COVID-19 Infection Outcomes?
Vaia Lambadiari, Foteini Kousathana, Athanasios Raptis, Κ Katogiannis, Alexander Kokkinos, Ignatios Ikonomidis
Abstract
In COVID-19 the immune system may react with an exacerbation of cytokine production known as a "cytokine storm" which leads to hyperinflammation and secondary hemophagocytic lymphohistiocytosis (sHLH) or else Macrophage Activation Syndrome (MAS). This is
Topics & Concepts
InflammasomeCoronavirus disease 2019 (COVID-19)Vascular permeabilityMedicineImmunologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Diabetes mellitus2019-20 coronavirus outbreakCytokineInflammationVirologyInternal medicineInfectious disease (medical specialty)DiseaseEndocrinologyOutbreakInflammasome and immune disordersCOVID-19 Clinical Research StudiesAdipokines, Inflammation, and Metabolic Diseases