Copper(<scp>i</scp>)-catalysed azide–alkyne cycloaddition and antiproliferative activity of mono- and bis-1,2,3-triazole derivatives
Tamer El Malah, Randa E. Abdel Mageid, Hanem M. Awad, Hany F. Nour
Abstract
A series of mono- and bis-1,2,3-triazole derivatives were prepared <italic>via</italic> the copper(<sc>i</sc>)-catalysed azide–alkyne cycloaddition between substituted aromatic derivatives, comprising one or two terminal alkyne groups and a selection of aromatic azides.
Topics & Concepts
ChemistryAlkyneCycloadditionAzideTriazoleCopper1,2,3-TriazoleCombinatorial chemistryClick chemistryMedicinal chemistryOrganic chemistryCatalysisClick Chemistry and ApplicationsProtein Degradation and InhibitorsSynthesis and Catalytic Reactions