Association of Attenuated Niacin Response With Inflammatory Imbalance and Prediction of Conversion to Psychosis From Clinical High-risk Stage
Tianhong Zhang, Xudong Xiao, Haisu Wu, Jiahui Zeng, JiaYi Ye, YuQing Gao, YeGang Hu, Lihua Xu, YanYan Wei, XiaoChen Tang, HaiChun Liu, Tao Chen, Xiaohua Liu, Chunbo Li, Linlin Zhou, Xuming Wu, Jijun Wang
Abstract
Attenuated niacin responses and changes in cytokine levels have been reported in schizophrenia. However, prior studies have typically focused on schizophrenia, and little is known about the association between niacin response and inflammatory imbalance in clinically high-risk psychosis (CHR). This study aimed to assess the niacin response to inflammatory imbalance for association with conversion to psychosis within 2 years. ) and maximal minus minimal blood flow response (Span) values were calculated for each subject. Serum cytokine levels were measured using enzyme-linked immunosorbent assay. Individuals with CHR were then divided into converters (CHR-C, n = 15) and non-converters (CHR-NC, n = 45) to psychosis based on their 2-year follow-up clinical status. = .018), but this correlation was nonsignificant in the CHR-NC group. Our findings indicate a significant association between niacin response and psychosis conversion outcomes in individuals with CHR. Compared with peripheral inflammatory cytokines, the niacin response can better predict conversion, although there may be an intersection between the two in biological mechanisms.