Indolizine-phenothiazine hybrids as the first dual inhibitors of tubulin polymerization and farnesyltransferase with synergistic antitumor activity
Iuliana-Monica Moise, Elena Bîcu, Amaury Farce, Joëlle Dubois, Alina Ghinet
Topics & Concepts
Farnesyltransferase inhibitorFarnesyltransferasePhenothiazineChemistryCytotoxicityCancer cellIndolizineIn vitroCancerCancer researchBiochemistryPharmacologyStereochemistryBiologyEnzymePrenylationGeneticsSynthesis and Reactivity of HeterocyclesCancer therapeutics and mechanismsCatalytic C–H Functionalization Methods