Cartilage repair mediated by thermosensitive photocrosslinkable TGFβ1-loaded GM-HPCH via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis
Xiongfa Ji, Zehua Lei, Meng Yuan, Hao Zhu, Xi Yuan, Wenbin Liu, Hongxu Pu, Jiawei Jiang, Yu Zhang, Xulin Jiang, Jun Xiao
Abstract
: The GM-HPCH + TGFβ1 hydrogel effectively promoted cartilage repair via immunomodulating macrophages, recruiting MSCs and promoting chondrogenesis; thus it is a promising injectable hydrogel for cartilage regeneration.
Topics & Concepts
ChondrogenesisSelf-healing hydrogelsCartilageMesenchymal stem cellBiomedical engineeringChemistryMaterials scienceCell biologyNanotechnologyMedicineAnatomyBiologyPolymer chemistryOsteoarthritis Treatment and MechanismsBone Tissue Engineering MaterialsSilk-based biomaterials and applications