Glutathione-responsive multifunctional nanoparticles based on mannose-modified pillar[5]arene for targeted antibiotic delivery against intracellular methicillin-resistant <i>S. aureus</i>
Haibo Peng, Beibei Xie, Xianfeng Cen, Jiaojiao Dai, Yuanwei Dai, Xiaohong Yang, Yun He
Abstract
GSH-responsive multifunctional antibiotic delivery system (WP5⊃G) was successfully developed. WP5⊃G could encapsulate linezolid (LZD) to form drug-loaded nanoparticles (LZD-WP5⊃G), improving the anti-intracellular MRSA activity of LZD with excellent biocompatibility.
Topics & Concepts
IntracellularGlutathionePillarAntibioticsMannoseNanoparticleChemistryMicrobiologyDrug deliveryNanotechnologyCombinatorial chemistryBiochemistryMaterials scienceBiologyEnzymeEngineeringStructural engineeringSupramolecular Chemistry and ComplexesLuminescence and Fluorescent MaterialsMolecular Sensors and Ion Detection