The impact of MOFs in pH-dependent drug delivery systems: progress in the last decade
Diptiman De, Prithidipa Sahoo
Abstract
, pore size and shape) and chemical properties. Drug delivery involves the administration of drugs using a suitable carrier for achieving treatment without unwanted side effects. In the last few years, several types of MOFs have been synthesized including Zn-based MOFs, MIL series MOFs, and Zr-based MOFs and evaluated for their use in different biomedical fields, especially drug delivery. After Fe, zinc is the second most available element in the body, and hence Zn-based MOFs can be considered enduring platforms for various biomedical uses, especially drug delivery applications. MIL series composites and Zr-based biomaterials are also suggested for several biomedical applications due to their good mechanical properties, biocompatibility, and bioactivity. This review highlights the different types of Zn-based and MIL series MOFs that have been used as suitable pH-responsive drug delivery systems and summarizes the Zr-based MOFs that have been used as suitable pH-responsive or reverse pH-responsive drug delivery systems and also discuss their drug-releasing phenomenon at different pH ranges.