Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl)pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)
Magda F. Mohamed, Nada S. Ibrahim, Amna A. Saddiq, Omar A. Almaghrabi, Maha E. Al-Hazemi, Hamdi M. Hassaneen, Ismail A. Abdelhamid
Abstract
A new chalcone series has been developed that may be useful in the treatment of lung cancer. The new series was confirmed by the different spectral tools. MTT assay was used to detect the cytotoxic effect of the novel chalcones against lung cancer cell line (A549). Molecular docking studies were performed on the most two effective chalcones 7b and 7c. Different molecular techniques were utilized to study the activity and the effect of two chalcones 7b and 7c on apoptosis of A549 cell line.
Topics & Concepts
ChalconeFuranChemistryLung cancerMTT assayA549 cellCell cultureCytotoxic T cellCytotoxicityApoptosisStereochemistryCancer researchCombinatorial chemistryBiochemistryBiologyOncologyOrganic chemistryMedicineIn vitroGeneticsSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsSynthesis and Biological Evaluation