<i>Spirulina</i> extract improves age-induced vascular dysfunction
Michał Majewski, Mercedes Klett‐Mingo, Carlos M. Verdasco‐Martín, Cristina Otero, Mercedes Ferrer
Abstract
CONTEXT: extracts, with antioxidant properties, increased recently. OBJECTIVE: aqueous extract (SAE) on the vascular function of the aorta from aged rats. MATERIALS AND METHODS: channel opener, cromakalim (CK); (ii) the vasoconstrictor response induced by KCl and noradrenaline (NA); (iii) the production of NO and superoxide anion, and (iv) the expression of the p-eNOS and HO-1 proteins. RESULTS: ) to ACh (control: -7.06 ± 0.11; SAE: -8.16 ± 0.21), SNP (control: -7.96 ± 0.16; SAE: -9.11 ± 0.14) and CK (control: -7.05 ± 0.39; SAE: -8.29 ± 0.53), and potentiated the response to KCl (1.3-fold) and to NA (1.7-fold). CONCLUSION: as a protection against vascular dysfunction.