The Two-Component System CopRS Maintains Subfemtomolar Levels of Free Copper in the Periplasm of Pseudomonas aeruginosa Using a Phosphatase-Based Mechanism
Lorena Novoa‐Aponte, Cheng Xu, Fernando C. Soncini, José Argüello
Abstract
exhibits a signal-dependent phosphatase activity controlling the activation of its cognate response regulator, distinct from previously described periplasmic Cu sensors. Importantly, the data show that the system is activated by copper levels compatible with the absence of free copper in the cell periplasm. These observations emphasize the diversity of molecular mechanisms that have evolved in bacteria to manage the copper cellular distribution.
Topics & Concepts
Periplasmic spacePseudomonas aeruginosaMechanism (biology)Component (thermodynamics)CopperChemistryPhosphataseMicrobiologyCell biologyBiochemistryBiologyBacteriaEnzymePhysicsGeneGeneticsEscherichia coliOrganic chemistryQuantum mechanicsThermodynamicsTrace Elements in HealthElectrochemical Analysis and ApplicationsBacterial biofilms and quorum sensing