A nickel(<scp>ii</scp>)-catalyzed enantioselective all-carbon-based inverse-electron-demand Diels–Alder reaction of 2-pyrones with indenes
Fangqing Zhang, Bing-Tao Ren, Yangbin Liu, Xiaoming Feng
Abstract
An asymmetric IEDDA reaction of 2-pyrones with indenes catalyzed by a chiral N , N ′-dioxide/Ni(OTf) 2 complex has been disclosed to construct highly functionalized hexahydrofluorenyl bridged-lactone scaffolds in high yields and ee.
Topics & Concepts
ChemistryEnantioselective synthesisCatalysisNickelDiels–Alder reactionCombinatorial chemistryOrganic chemistryStereochemistryMedicinal chemistrySynthetic Organic Chemistry MethodsBiological Activity of Diterpenoids and BiflavonoidsAsymmetric Synthesis and Catalysis