Glucosylceramide Associated with Gaucher Disease Forms Amyloid-like Twisted Ribbon Fibrils That Induce α-Synuclein Aggregation
Ashim Paul, Guy Jacoby, Dana Laor Bar‐Yosef, Roy Beck, Ehud Gazit, Daniel Segal
Abstract
inhibitors of proteinaceous amyloids effectively inhibited aggregation of GlcCer. This study contributes to the growing evidence of cross-talk between proteinaceous amyloids and amyloid-like aggregates of metabolites accumulated in diseases and suggests these aggregates as therapeutic targets.
Topics & Concepts
FibrilAmyloid (mycology)Amyloid fibrilGlucocerebrosidaseProtein aggregationAmyloid βDiseaseBiophysicsChemistryMaterials scienceNanotechnologyMedicineBiochemistryBiologyPathologyLysosomal Storage Disorders ResearchParkinson's Disease Mechanisms and TreatmentsCarbohydrate Chemistry and Synthesis