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Telehealth virtual reality intervention reduces chronic pain in a randomized crossover study

Luana Colloca, Anna Han, Rachel Massalee, Nandini Raghuraman, Rachel L. Cundiff-O’Sullivan, Giancarlo Colloca, Yang Wang

2025npj Digital Medicine17 citationsDOIOpen Access PDF

Abstract

The efficacy of telehealth Virtual Reality (VR) for chronic pain, a promising digital intervention, remains underexplored due to methodological challenges. In a 5-week crossover trial, we compared VR to matched audio content control in individuals with chronic pain. VR significantly reduced pain intensity, anxiety, and pain interference while improving mood and sleep quality. Findings highlight the potential of telehealth-based VR for addressing real-world challenges in managing chronic pain. ISRCTN12473220 (07/18/2023).

Topics & Concepts

TelehealthCrossover studyChronic painAnxietyIntervention (counseling)Physical therapyMoodVirtual realityRandomized controlled trialMedicineSleep qualityPhysical medicine and rehabilitationPsychologyTelemedicineHealth careClinical psychologyNursingAlternative medicinePsychiatryInsomniaComputer scienceInternal medicineEconomicsPlaceboPathologyArtificial intelligenceEconomic growthMusculoskeletal pain and rehabilitationPediatric Pain Management TechniquesPain Management and Placebo Effect
Telehealth virtual reality intervention reduces chronic pain in a randomized crossover study | Litcius