Rh-catalyzed alkoxycarbonylation of unactivated alkyl chlorides
Peng Wang, Yaxin Wang, Helfried Neumann, Matthias Beller
Abstract
more active alkyl iodides. In the presence of a Rh(i)-DPPP catalyst system diverse esters (81 examples) including industrially relevant acetates from chloro- and dichloromethane can be prepared in a straightforward manner in up to 95% isolated yield. The used ligand not only affects the selectivity of the carbonylation reaction but also controls the selectivity of the preceding halide exchange step.
Topics & Concepts
AlkylCatalysisChemistryMedicinal chemistryOrganic chemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis