Metal- and additive-free radical-triggered nitration/cyclization to construct indolo[2,1-<i>α</i>]isoquinoline and benzimidazo[2,1-<i>a</i>]isoquinolin-6(5<i>H</i>)-one derivatives using<i>t</i>-BuONO as nitro reagents

Abstract

-BuONO was used as a nitro reagent. Due to mild reaction conditions, a variety of functional groups could be tolerated to give the corresponding products in moderate to good yields. Moreover, this nitration process could be scaled-up and the nitro group could be readily converted into the amino group, which may find applications in synthetic and medicinal chemistry.

Topics & Concepts