Design and evaluation of sustained release mucoadhesive film of sumatriptan succinate containing grafted co-polymer as the platform
Surajpal Verma, Rajiv Kumar Tonk, Mohammed Albratty, Hassan A. Alhazmi, Asim Najmi, Ravi Kumar, Mahesh Kumar, Mohamad Taleuzzaman, Gourav Swami, Md Shamsher Alam
Abstract
Purpose: The primary goal of this research is to improve the bioavailability and efficacy of Sumatriptan succinate by incorporating it in the mucoadhesive film for the treatment of migraine. Mucoadhesive film offers an excellent substitute to deliver the drug in the systemic circulation and eliminate the chance of first-pass metabolism. Method: factorial method based on dependent variables such as Drug content (%), Swelling index (%), Folding endurance (Number of times), and Mucoadhesive strength (g). Results: drug release within 2 h. That signified that the developed formulation provides sustained release due to presence of grafted co-polymer. Conclusion: Formulation holding drug-loaded grafted film showed decent sustained and controlled drug release characteristics compared to a pure drug suspension. S9 formulation showed better results than other formulations in drug content, swelling index, folding endurance, and mucoadhesive strength, which is further used to treat migraine.