Electrophilic Hypervalent Trifluoromethylthio-Iodine(III) Reagent
Xiaoguang Yang, Ke Zheng, Chi Zhang
Abstract
Herein we report the design and synthesis of hypervalent trifluoromethylthio-iodine(III) reagent 1 and the elucidation of its structure by NMR spectroscopy and X-ray crystallography. The trifluoromethylthiolation reactions of 1 with various nucleophiles were explored, and this compound was found to be a versatile electrophilic reagent for the transfer of a trifluoromethylthio group (−SCF3). The hydrogen-bonding mode responsible for the activation of 1 by the solvent 1,1,1,3,3,3-hexafluoro-2-propanol was investigated both experimentally and computationally.
Topics & Concepts
Hypervalent moleculeChemistryReagentElectrophileNucleophileIodineSolventNuclear magnetic resonance spectroscopyMedicinal chemistryOrganic chemistryCombinatorial chemistryCatalysisFluorine in Organic ChemistryOxidative Organic Chemistry ReactionsSynthesis and Catalytic Reactions