Electrochemically-initiated intramolecular 1,2-amino oxygenation of alkynes: facile access to formyl- and acyl-substituted indolizines
Qi‐Liang Yang, Rui-Cong Ma, Zhi-Hao Li, Wanwan Li, Gui‐Rong Qu, Hai‐Ming Guo
Abstract
An environmentally benign electrooxidative approach to the intramolecular aminooxygenation of alkynes through an electrophilic cyclization reaction has been developed, providing an efficient approach toward diverse formyl- and acyl-substituted indolizines.
Topics & Concepts
ChemistryIntramolecular forceElectrophileCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisSynthesis and Reactivity of HeterocyclesCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods