A diselenide bond-containing ROS-responsive ruthenium nanoplatform delivers nerve growth factor for Alzheimer's disease management by repairing and promoting neuron regeneration
Xiaoyu Yuan, Zhi Jia, Jin Li, Yanan Liu, Yuqin Huang, Youcong Gong, Xian Guo, Xu Chen, Jieqiong Cen, Jie Liu
Abstract
studies demonstrate that R@NGF-Se-Se-Ru nanoclusters decrease Aβ deposits, inhibit Aβ-induced cytotoxicity, and promote neurite outgrowth. The study confirms that promoting both Aβ clearance and neuron regeneration is an important therapeutic target for anti-AD drugs and provides a novel insight for AD therapy.
Topics & Concepts
NanoclustersNeuriteRegeneration (biology)Nerve growth factorNeuronCytotoxicityRutheniumReactive oxygen speciesChemistryCell biologyCancer researchMaterials scienceBiophysicsMedicineNeuroscienceNanotechnologyBiochemistryBiologyIn vitroReceptorCatalysisCholinesterase and Neurodegenerative DiseasesNanoplatforms for cancer theranosticsGraphene and Nanomaterials Applications