The phototoxic effect of a gold-antibody-based nanocarrier of phthalocyanine on melanoma monolayers and tumour spheroids
Nkune Williams Nkune, Heidi Abrahamse
Abstract
bioavailability and phototoxicity in two and three-dimensional tumour models. In summary, we demonstrated that this nanobioconjugate showed significant inhibitory effects on both melanoma models due to increased ROS yields and bioavailability of the melanoma cells compared to free ZnPcS
Topics & Concepts
NanocarriersPhototoxicitySpheroidMonolayerPhthalocyanineMelanomaChemistryCancer researchMedicineIn vitroBiochemistryDrug deliveryOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesPhotoacoustic and Ultrasonic Imaging