Protein/AS01B vaccination elicits stronger, more Th2-skewed antigen-specific human T follicular helper cell responses than heterologous viral vectors
Carolyn M. Nielsen, Ane Ogbe, Isabela Pedroza‐Pacheco, Susanne E. Doeleman, Yue Chen, Sarah E. Silk, Jordan R. Barrett, Sean C. Elias, Kazutoyo Miura, Ababacar Diouf, Martino Bardelli, Rebecca A. Dabbs, Lea Barfod, Carole A. Long, Barton F. Haynes, Ruth Payne, Angela M. Minassian, Todd Bradley, Simon J. Draper, Persephone Borrow
Abstract
as compared to a Th1/Tfh1 skew with viral vectors. These data highlight the impact of vaccine platform on the cTfh cell response driving humoral immunity, associating a high-magnitude, Th2-biased cTfh response with potent antibody production.
Topics & Concepts
HeterologousBiologyAntigenVirologyImmunologyAdjuvantAntibodyVaccinationImmune systemHumoral immunityGeneGeneticsImmune Cell Function and InteractionT-cell and B-cell ImmunologySARS-CoV-2 and COVID-19 Research