Islet O-GlcNAcylation Is Required for Lipid Potentiation of Insulin Secretion through SERCA2
Amber Lockridge, Seokwon Jo, Eric Gustafson, NIKLAS E. DAMBERG, Ramkumar Mohan, Miranda Olson, Juan E. Abrahante, Emilyn U. Alejandro
Abstract
ATPase SERCA2 as a β cell O-GlcNAcylated protein in mice and humans that is able to rescue palmitate-stimulated insulin secretion through pharmacological activation. This study reveals an important physiological role for β cell O-GlcNAcylation in sensing and responding to obesity, with therapeutic implications for managing the relationship between type 2 diabetes and its most common risk factor.
Topics & Concepts
Endoplasmic reticulumInternal medicineEndocrinologyIsletInsulinBiologySecretionPancreatic isletsLong-term potentiationCell biologyMedicineReceptorGlycosylation and Glycoproteins ResearchPancreatic function and diabetesGalectins and Cancer Biology