CD1d1 intrinsic signaling in macrophages controls NLRP3 inflammasome expression during inflammation
Shan Cui, Chenhui Wang, Weizhi Bai, Jiao Li, Yue Pan, Xiaoyong Huang, Han Yang, Zeqing Feng, Qun Xiang, Lei Fei, Lixin Zheng, Jian Huang, Qinggao Zhang, Yuzhang Wu, Yongwen Chen
Abstract
in macrophages. Therefore, the counterbalancing role of CD1d1 in macrophages appears to determine severity of DSS-mediated colitis in mice. These findings propose new intervention strategies for treating IBD and other inflammatory disorders.
Topics & Concepts
InflammasomeInflammationCell biologySignal transductionExpression (computer science)ImmunologyBiologyChemistryComputer scienceProgramming languageInflammasome and immune disordersImmune Cell Function and InteractionIL-33, ST2, and ILC Pathways