TMEM41B Is an Interferon-Stimulated Gene That Promotes Pseudorabies Virus Replication
Xiu‐Qing Li, Lei Zeng, Dong-Ge Liang, Yan-Li Qi, Guo‐Yu Yang, Kai Zhong, Bei‐Bei Chu, Jiang Wang
Abstract
PRV belongs to the alphaherpesvirus subfamily and can establish and maintain a lifelong latent infection in pigs. As such, an intermittent active cycle presents great challenges to the prevention and control of PRV disease and is responsible for serious economic losses to the pig breeding industry. Studies have shown that lipids play a crucial role in PRV proliferation. Thus, the manipulation of lipid metabolism may represent a new perspective for the prevention and treatment of PRV. In this study, we report that the ER transmembrane protein TMEM41B is a novel ISG involved in PRV infection by regulating lipid synthesis. Therefore, our findings indicate that targeting TMEM41B may be a promising approach for the development of PRV vaccines and therapeutics.