Quantitation of autoinhibitory defects in pathogenic SHP2 mutants by differential scanning fluorimetry
Anna Serbina, Anthony C. Bishop
Topics & Concepts
MutantProtein tyrosine phosphatasePhosphataseHomology (biology)Proto-oncogene tyrosine-protein kinase SrcChemistryCell biologyEnzymeBiochemistryBiologyPhosphorylationBiophysicsAmino acidGeneProtein Tyrosine PhosphatasesGalectins and Cancer BiologyProtein Kinase Regulation and GTPase Signaling