Exosomes facilitate intercellular communication between uterine perivascular adipose tissue and vascular smooth muscle cells in pregnant rats
Oluwatobiloba Osikoya, Spencer C. Cushen, Jennifer J. Gardner, Megan Raetz, B. Nagarajan, Sangram Raut, Styliani Goulopoulou
Abstract
Uterine perivascular adipose tissue secretes exosome-like vesicles, which are internalized by their adjacent uterine vascular smooth muscle cells. Consideration of the exosomal communication between adipose tissue and vascular smooth muscle cells in the uterine circulation in mathematical models and experimental designs may help us to improve understanding of mechanisms underlying uterine artery adaptive responses to a healthy pregnancy and during pregnancy complications.
Topics & Concepts
MicrovesiclesAdipose tissueVascular smooth muscleExosomeUterine arterySmooth muscleVascular tissueIntracellularVascular wallMedicineBiologyInternal medicineEndocrinologyPregnancyCell biologyPathologymicroRNAGestationGeneBiochemistryGeneticsBotanyCardiovascular Disease and AdiposityPregnancy and preeclampsia studiesExtracellular vesicles in disease