Synthesis and characterization of new pyrazole–tetrazole derivatives as new vasorelaxant agents
Mounir Cherfi, Ikram Dib, Tarik Harit, Abderrahim Ziyyat, Fouad Malek
Abstract
Abstract The synthesis of new functionalized tetrazole–pyrazole compounds is reported. They were fully characterized by spectroscopy and spectrometry methods. The vasorelaxant potency of these molecules was also investigated. All compounds showed a good vasorelaxant activity but the Compound 6 “ethyl 1‐((2‐(3‐bromopropyl)‐2H‐tetrazol‐5‐yl)methyl)‐5‐methyl‐1H‐pyrazole‐3‐carboxylate” seems to have the highest effect, which reached 70% at 10 −4 M concentration. This effect was partially endothelium‐dependent; also, the vasorelaxant pattern of this compound was quite similar to that of the verapamil.
Topics & Concepts
PyrazoleChemistryTetrazoleVerapamilPotencyMoleculeStereochemistryCombinatorial chemistryIn vitroOrganic chemistryBiochemistryCalciumSynthesis of Tetrazole DerivativesSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activity