The Lipidome Fingerprint of Longevity
Mariona Jové, Natàlia Mota‐Martorell, Irene Pradas, José Daniel Galo‐Licona, Meritxell Martin‐Garí, Èlia Òbis, Joaquím Sol, Reinald Pamplona
Abstract
Lipids were determinants in the appearance and evolution of life. Recent studies disclose the existence of a link between lipids and animal longevity. Findings from both comparative studies and genetics and nutritional interventions in invertebrates, vertebrates, and exceptionally long-lived animal species-humans included-demonstrate that both the cell membrane fatty acid profile and lipidome are a species-specific optimized evolutionary adaptation and traits associated with longevity. All these emerging observations point to lipids as a key target to study the molecular mechanisms underlying differences in longevity and suggest the existence of a lipidome profile of long life.