Quaternization drives spleen-to-lung tropism conversion for mRNA-loaded lipid-like nanoassemblies
Yixuan Huang, Jiacai Wu, Sanpeng Li, Zhen Liu, Zhenghua Li, Boping Zhou, Bin Li
Abstract
Quaternization provides an alternative method for design of new lung-targeted mRNA delivery systems without incorporation of targeting ligands, which should extend the therapeutic applicability of mRNA to lung diseases.
Topics & Concepts
SpleenMessenger RNATropismIn vitroLungTranslation (biology)ChemistryImmune systemImmunologyBiologyMedicineBiochemistryInternal medicineVirusGeneRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesBacteriophages and microbial interactions