Effect of Enrofloxacin on the Microbiome, Metabolome, and Abundance of Antibiotic Resistance Genes in the Chicken Cecum
Boheng Ma, De Wang, Xueran Mei, Changwei Lei, Cui Li, Hongning Wang
Abstract
In this study, we investigated changes in the cecum flora, metabolites, and abundances of fluoroquinolone antibiotic resistance genes in chickens following the use of different concentrations of enrofloxacin. These results were used to determine the effects of enrofloxacin on chick physiology and the important flora and metabolites that might contribute to these effects. In addition, these results could help in assessing the effect of enrofloxacin concentrations on host metabolism. Our findings could help guide the rational use of antibiotics and mitigate the negative effects of antibiotics on the host.
Topics & Concepts
EnrofloxacinCecumBiologyMicrobiologyMetabolomeMicrobiomeAntibioticsAntibiotic resistanceGut floraMetaboliteBiochemistryEcologyGeneticsCiprofloxacinGut microbiota and healthPharmaceutical and Antibiotic Environmental ImpactsAquaculture disease management and microbiota