The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease
Rika Ohkubo, Wei‐Chieh Mu, Chih-Ling Wang, Zehan Song, Marine Barthez, Yifei Wang, Nathaniel Mitchener, Rasul Abdullayev, Yeong Rim Lee, Yuze Ma, Megan Curtin, Suraj Srinivasan, Xingjia Zhang, Fanghan Yang, Peter H. Sudmant, Angela Oliveira Pisco, Norma Neff, Cole M. Haynes, Danica Chen
Abstract
repletion reduces the ISR, rescues the dysregulated somatotroph axis, and alleviates NAFLD. These results establish that the hepatic ISR suppresses the somatotroph axis to control cell fate decisions and liver damage in NAFLD.
Topics & Concepts
Somatotropic cellNonalcoholic fatty liver diseaseEndocrinologyInternal medicineFibrosisMedicineFatty liverCancer researchBiologyPituitary glandDiseaseHormoneEndoplasmic Reticulum Stress and DiseaseLiver Disease Diagnosis and TreatmentAdipose Tissue and Metabolism