Diosmin enhances the anti-angiogenic activity of sildenafil and pentoxifylline against hepatopulmonary syndrome via regulation of TNF-α/VEGF, IGF-1/PI3K/AKT, and FGF-1/ANG-2 signaling pathways
Adel G. Bakr, Ali H. El‐Bahrawy, Hesham H. Taha, Fares E.M. Ali
Topics & Concepts
Hepatopulmonary syndromeProtein kinase BPentoxifyllineDiosminEnosPI3K/AKT/mTOR pathwayPharmacologyEndocrinologyInternal medicineAngiogenesisOxidative stressMedicineChemistryNitric oxideCirrhosisSignal transductionNitric oxide synthaseBiochemistryAntioxidantPortal hypertensionFlavonoidNitric Oxide and Endothelin EffectsLiver Disease and TransplantationEicosanoids and Hypertension Pharmacology