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Genetics of the human microglia regulome refines Alzheimer’s disease risk loci

Roman Kosoy, John F. Fullard, Biao Zeng, Jaroslav Bendl, Pengfei Dong, Samir Rahman, Steven P. Kleopoulos, Zhiping Shao, Kiran Girdhar, Jack Humphrey, Kátia de Paiva Lopes, Alexander W. Charney, Brian H. Kopell, Towfique Raj, David A. Bennett, Christopher P. Kellner, Vahram Haroutunian, Gabriel E. Hoffman, Panos Roussos

2022Nature Genetics169 citationsDOIOpen Access PDF

Topics & Concepts

BiologyMicrogliaEnhancerTranscriptomeGeneticsGenome-wide association studyComputational biologyChromatinEpigenomicsGeneTREM2Transcription factorDiseaseGene expressionSingle-nucleotide polymorphismImmunologyGenotypeMedicinePathologyInflammationDNA methylationNeuroinflammation and Neurodegeneration MechanismsBioinformatics and Genomic NetworksEpigenetics and DNA Methylation
Genetics of the human microglia regulome refines Alzheimer’s disease risk loci | Litcius