Hypoxia-induced Nur77 activates PI3K/Akt signaling <i>via</i> suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition
Zeyu Shi, Sally K. Y. To, Shuaishuai Zhang, Shan Deng, Margarita Artemenko, Minda Zhang, Juan Tang, Jin-Zhang Zeng, Alice S.T. Wong
Abstract
Our data uncovered a novel mechanistic link connecting Nur77, Akt, and invasive properties of CRC in the hypoxic microenvironment.
Topics & Concepts
Cancer researchEpithelial–mesenchymal transitionGene knockdownProtein kinase BPI3K/AKT/mTOR pathwayNerve growth factor IBMetastasisBiologymicroRNADicerTumor microenvironmentCell biologyChemistrySmall interfering RNASignal transductionTranscription factorCell cultureTransfectionCancerNuclear receptorBiochemistryTumor cellsGeneticsGeneNuclear Receptors and SignalingCircular RNAs in diseasesRNA Interference and Gene Delivery